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This paper considers approaches to risk and benefit assessment that could be applied to advances in the life sciences with possible “dual-use” implications for bioweapons development. The paper describes the components of scientific risk assessment and outlines existing risk assessment tools of particular relevance to the Biological Weapons Convention, including those developed by the U.S. National Science Advisory Board for Biosecurity (NSABB), Jonathan B. Tucker, and the U.S. National Academy of Sciences. Finally, it highlights additional risk management tools and discusses approaches to weighing benefits.